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Capto adhere5/17/2023 ![]() Fulfills industrial demands for security of supply, robust performance, and regulatory support. The Capto Adhere ligand, N-benzyl-N-methyl ethanol amine, has a high ion-exchange capacity mixed with an aromatic moiety, which also promotes its stability.Cost-savings by eliminating the need for column preparation, packing, and validation procedures.Standardized column formats allow reduced column cost and off-the-shelf availability for short delivery lead times.Robust column design and validated packing methods enable consistent column performance.Key benefits of ReadyToProcess columns include: Together with a Protein A capture step, like MabSelect SuRe, Capto adhere allows the design of a two-step chromatographic process for mAbs. Together with a Protein A capture step, like MabSelect SuRe, Capto adhere allows the design of a two-step chromatographic process for mAbs.įor optimized performance of Capto adhere, screening and optimization of loading conditions is recommended, preferably using modern high-throughput process development tools, such as PreDictor 96-well filter plates. Capto adhere ImpRes is a strong ion exchanger with multimodal functionality designed for polishing of monoclonal antibodies (MAbs). Capto adhere can remove key contaminants such as DNA, host cell proteins (HCP), leached protein A, dimers and larger aggregates, and viruses in a single step. Capto adhere can remove key contaminants such as DNA, host cell proteins (HCP), leached protein A, dimers and larger aggregates, and viruses in a single step. Capto adhere is a multimodal anion exchange chromatography resin for intermediate purification and polishing of monoclonal antibodies after the Protein A capture step, giving the possibility to design a two-step chromatographic downstream process. The strong multimodal ligand gives a different selectivity compared with traditional ion exchangers. The resin is composed of a rigid, high-flow agarose matrix and a novel multimodal ligand. Enables a two-step chromatographic process
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